Z-LVG-CHN2 is a cell-permeable and irreversible inhibitor of cysteine proteinase. Z-LVG-CHN2 is a tripeptide derivative and mimics part of the human cysteine proteinase-binding center. Z-LVG-CHN2 displays an inhibition on HSV whereas no significant effect on poliovirus replication. Z-LVG-CHN2 effectively blocks SARS-COV-2 replication (EC50=190 nM) via inhibition of SARS-COV-2 3CL pro protease.
|Solubility (25°C)||DMSO 90 mg/mL|
Powder -20°C 3 years ; 4°C 2 years
In solvent -80°C 6 months ; -20°C 1 month
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
 Laura Riva, et al. Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing
 Laura Riva, et al. A Large-scale Drug Repositioning Survey for SARS-CoV-2 Antivirals
 L Bjrck, et al. Bacterial growth blocked by a synthetic peptide based on the structure of a human proteinase inhibitor
 L Bjrck, et al. Cystatin C, a human proteinase inhibitor, blocks replication of herpes simplex virus
 L Bjrck. Proteinase inhibition, immunoglobulin-binding proteins and a novel antimicrobial principle
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