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Cat. No. M14309
Z-LVG-CHN2 Structure
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Biological Activity

Z-LVG-CHN2 is a cell-permeable and irreversible inhibitor of cysteine proteinase. Z-LVG-CHN2 is a tripeptide derivative and mimics part of the human cysteine proteinase-binding center. Z-LVG-CHN2 displays an inhibition on HSV whereas no significant effect on poliovirus replication. Z-LVG-CHN2 effectively blocks SARS-COV-2 replication (EC50=190 nM) via inhibition of SARS-COV-2 3CL pro protease.

Chemical Information
Molecular Weight 445.51
CAS Number 119670-30-3
Solubility (25°C) DMSO 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Laura Riva, et al. Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing

[2] Laura Riva, et al. A Large-scale Drug Repositioning Survey for SARS-CoV-2 Antivirals

[3] L Bjrck, et al. Bacterial growth blocked by a synthetic peptide based on the structure of a human proteinase inhibitor

[4] L Bjrck, et al. Cystatin C, a human proteinase inhibitor, blocks replication of herpes simplex virus

[5] L Bjrck. Proteinase inhibition, immunoglobulin-binding proteins and a novel antimicrobial principle

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Keywords: Z-LVG-CHN2 supplier, Cathepsin, inhibitors, activators

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