Yamogenin (Neodiosgenin) antagonizes the activation of the liver X receptor (LXR) in luciferase ligand assay. Yamogenin (Neodiosgenin) inhibits triacylglyceride (TG) accumulation through the suppression of gene expression of fatty acid synthesis in HepG2 hepatocytes.
|Solubility (25°C)||Ethanol 8 mg/mL|
Powder -20°C 3 years ; 4°C 2 years
In solvent -80°C 6 months ; -20°C 1 month
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
 Ahmed A Zaki, et al. Steroids. Cytotoxic steroidal saponins from Panicum turgidum Forssk
 Jing Gong, et al. J Ethnopharmacol. Effect of fenugreek on hyperglycaemia and hyperlipidemia in diabetes and prediabetes: A meta-analysis
 Sayaka Moriwaki, et al. Biosci Biotechnol Biochem. Yamogenin in fenugreek inhibits lipid accumulation through the suppression of gene expression in fatty acid synthesis in hepatocytes
 le T Quyen, et al. Planta Med. Steroid Alkaloids and Yamogenin from Solanum spirale1
 R Hardman, et al. Planta Med. The effect of ripening and aqueous incubation on the yield of diosgenin and yamogenin from the fruits of Balanites pedicellaris
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