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Yamogenin

Cat. No. M10138
Yamogenin Structure
Synonym:

Diosgenin

Size Price Availability Quantity
10mg USD 200  USD200 In stock
50mg USD 440  USD440 In stock
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Quality Control & Documentation
Biological Activity

Yamogenin (Neodiosgenin) antagonizes the activation of the liver X receptor (LXR) in luciferase ligand assay. Yamogenin (Neodiosgenin) inhibits triacylglyceride (TG) accumulation through the suppression of gene expression of fatty acid synthesis in HepG2 hepatocytes.

Chemical Information
Molecular Weight 414.6
Formula C27H42O3
CAS Number 512-06-1
Solubility (25°C) Ethanol 8 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ahmed A Zaki, et al. Steroids. Cytotoxic steroidal saponins from Panicum turgidum Forssk

[2] Jing Gong, et al. J Ethnopharmacol. Effect of fenugreek on hyperglycaemia and hyperlipidemia in diabetes and prediabetes: A meta-analysis

[3] Sayaka Moriwaki, et al. Biosci Biotechnol Biochem. Yamogenin in fenugreek inhibits lipid accumulation through the suppression of gene expression in fatty acid synthesis in hepatocytes

[4] le T Quyen, et al. Planta Med. Steroid Alkaloids and Yamogenin from Solanum spirale1

[5] R Hardman, et al. Planta Med. The effect of ripening and aqueous incubation on the yield of diosgenin and yamogenin from the fruits of Balanites pedicellaris

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Keywords: Yamogenin, Diosgenin supplier, Liver X Receptor, inhibitors, activators

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