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Wf-516 

Cat. No. M29884

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Wf-516  Structure

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Quality Control & Documentation
Biological Activity

Wf-516 is an inhibitor of 5-HT reuptake, and an antagonist of 5-HT1A and 5-HT2A receptors, with Ki of 5 nM and 40 nM for 5-HT1A receptor and 5-HT2A receptor in humans, respectively, and has potent antidepressant activity.

Chemical Information
Molecular Weight 502.39
Formula C25H25Cl2N3O4
CAS Number 310392-94-0
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Takeaki Saijo, et al. PLoS One. Presynaptic selectivity of a ligand for serotonin 1A receptors revealed by in vivo PET assays of rat brain

[2] Takeaki Saijo, et al. Int J Neuropsychopharmacol. Utility of small-animal positron emission tomographic imaging of rats for preclinical development of drugs acting on the serotonin transporter

[3] M El Mansari, et al. Naunyn Schmiedebergs Arch Pharmacol. In vivo electrophysiological assessment of the putative antidepressant Wf-516 in the rat raphe dorsalis, locus coeruleus and hippocampus

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  Catalog
Abmole Inhibitor Catalog




Keywords: Wf-516  supplier, Serotonin Transporter, inhibitors, activators

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