Inhibitor
| Cat.No. | Name | Information |
|---|---|---|
| M43921 | Centanafadine hydrochloride | Centanafadine hydrochloride is a potential first-in-class norepinephrine (NE), dopamine (DA), and 5-hydroxytryptamine (5-HT) reuptake inhibitor (NDSRI) with IC50 values of 6 nM, 38 nM, and 83 nM, respectively. It can be used in studies related to attention-deficit/hyperactivity disorder (ADHD). |
| M42692 | Tampramine fumarate | Tampramine fumarate is a potent, selective, noncompetitive NE reuptake inhibitor. |
| M31247 | Ampreloxetine hydrochloride | Ampreloxetine (TD-9855) hydrochloride is an orally active and CNS-penetrant inhibitor of Norepinephrine transporter (NET) and Serotonin 5-HT uptake transporter (SERT). Ampreloxetine hydrochloride binds norepinephrine transporters (NET) and serotonin transporters (SERT) with EC50 values of 11.7 ng/mL and 50.8 ng/mL, respectively, in plasma. |
| M30987 | ZZL-7 | ZZL-7 is a fast-onset antidepressant agent. ZZL-7 works by disrupting the interaction between the serotonin transporter (SERT) and neuronal nitric oxide synthase (nNOS) in the dorsal raphe nucleus (DRN). ZZL-7 can cross the blood-brain barrier readily. ZZL-7 can be used for the research of major depressive disorder (MDD). |
| M30979 | Dextromilnacipran | Dextromilnacipran (F2696; (1R,2S)-milnacipran), an enantiomer of milnacipran, is a selective serotonin and norepinephrine (5-HT/NE) reuptake inhibitor. Dextromilnacipran also is a human alpha-adrenergic receptor antagonist, with an IC50 of 3.4 μM. |
| M30855 | Bupropion hydrobromide | Bupropion (Amfebutamone) hydrobromide is an orally active, selective serotonin reuptake inhibitor (SSRI).Bupropion hydrobromide block dopamine (DA) uptake or Methamphetamine-induced DA release with IC50s of 1.76 μM and 14.2 μM, respectively. Bupropion hydrobromide is an atypical antidepressant that can be used for the research of smoking cessation aid. |
| M29884 | Wf-516 | Wf-516 is an inhibitor of 5-HT reuptake, and an antagonist of 5-HT1A and 5-HT2A receptors, with Ki of 5 nM and 40 nM for 5-HT1A receptor and 5-HT2A receptor in humans, respectively, and has potent antidepressant activity. |
| M27911 | Edivoxetine hydrochloride | Edivoxetine (hydrochloride) is a selective and potent norepinephrine reuptake inhibitor (NERI) being used in depressive disorder or attention-deficit/hyperactivity disorder. |
| M27910 | Dapoxetine | Dapoxetine (LY-210448) is an orally active and selective serotonin reuptake inhibitor (SSRI). Dapoxetine can be used for the research of premature ejaculation (PE). |
| M27837 | (S)-Fluoxetine hydrochloride | (S)-Fluoxetine hydrochloride, an antidepressant, is serotonin reuptake inhibitor (SSRI). |
| M20793 | Amitriptyline | Amitriptyline (MK-230, N-750, Ro41575) is an inhibitor of the serotonin transporter (SERT) and norepinephrine transporter (NET) with Ki values of 3.45 nM and 13.3 nM, respectively, and also inhibits the histamine receptor H1, the histamine receptor H4, 5-HT2, and the Sigma 1 receptor with Ki values of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively. It can also inhibit histamine receptor H1, histamine receptor H4, 5-HT2 and Sigma 1 receptor with Ki values of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively, and can be used in studies of depression and neuropathic pain. |
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