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WF-47-JS03 is a potent and selective RET kinase inhibitor with more than 500-fold selectivity for the kinase insertion domain receptor (KDR).WF-47-JS03 acts on Ba/F3 cells transfected with KIF5B-RET and LC-2/ad lung cancer cells transfected with CCDC6-RET with IC50s of 1.7 nM and 5.3 nM, respectively. crossed the blood-brain barrier.
| Molecular Weight | 514.66 |
| Formula | C30H38N6O2 |
| Solubility (25°C) | DMSO : 62.5 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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