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Selpercatinib (LOXO-292) is a first-in-class, highly selective and potent small molecule RET inhibitor with good blood-brain barrier (BBB) penetration. and RET (G810R) with IC50 values of 14.0 nM, 24.1 nM and 530.7 nM, respectively.
| Molecular Weight | 525.6 |
| Formula | C29H31N7O3 |
| CAS Number | 2152628-33-4 |
| Solubility (25°C) | DMSO 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] No authors listed. Selpercatinib
[3] Lori J Wirth, et al. Efficacy of Selpercatinib in RET-Altered Thyroid Cancers
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