Certificate of Analysis
| Product Name: | Selpercatinib (LOXO-292) |
| Catalog Number: | M9900 |
| CAS Number: | 2152628-33-4 |
Physical and Chemical Properties
| Formula: | C29H31N7O3 |
| Molecular Weight: | 525.6 |
| Solubility: | DMSO 20 mg/mL |
| Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | 99.98% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | Selpercatinib (LOXO-292) is a first-in-class, highly selective and potent small molecule RET inhibitor with good blood-brain barrier (BBB) penetration. and RET (G810R) with IC50 values of 14.0 nM, 24.1 nM and 530.7 nM, respectively. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |