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SPR719

Cat. No. M28299

All AbMole products are for research use only, cannot be used for human consumption.

SPR719 Structure
Synonym:

VXc-486

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Quality Control & Documentation
Biological Activity

SPR719 (VXc-486) is a gyrase B inhibitor, with bactericidal activity. SPR719 potently inhibits multiple agent-sensitive isolates and drug-resistant isolates of Mycobacterium tuberculosis, with MICs of 0.03 to 0.30 μg/ml and 0.08 to 5.48 μg/ml, respectively.

Chemical Information
Molecular Weight 428.46
Formula C21H25FN6O3
CAS Number 1384984-18-2
Form Solid
Solubility (25°C) DMSO 20 mg/mL (ultrasonic and adjust pH to 2 with HCl)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Wassihun Wedajo Aragaw, et al. Microbiol Spectr. In Vitro Resistance against DNA Gyrase Inhibitor SPR719 in Mycobacterium avium and Mycobacterium abscessus

[2] Sacha J Pidot, et al. PLoS Negl Trop Dis. In vitro activity of SPR719 against Mycobacterium ulcerans, Mycobacterium marinum and Mycobacterium chimaera

[3] Dereje Abate Negatu, et al. Antimicrob Agents Chemother. Piperidine-4-Carboxamides Target DNA Gyrase in Mycobacterium abscessus

[4] Lian J Pennings, et al. Antimicrob Agents Chemother. The Benzimidazole SPR719 Shows Promising Concentration-Dependent Activity and Synergy against Nontuberculous Mycobacteria

[5] Barbara A Brown-Elliott, et al. Antimicrob Agents Chemother. In Vitro Susceptibility Testing of a Novel Benzimidazole, SPR719, against Nontuberculous Mycobacteria

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Keywords: SPR719, VXc-486 supplier, Topoisomerase, inhibitors, activators

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