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VU0119498

Cat. No. M9607

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VU0119498 Structure
Synonym:

VU-0119498

Size Price Availability Quantity
10mg USD 165  USD165 In stock
25mg USD 295  USD295 In stock
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Quality Control & Documentation
Biological Activity

VU0119498 is a M1 muscarinic receptor agonist (EC50 = 3.1 μM) and pan mAChR M3, M5 positive allosteric modulator (PAM).

Chemical Information
Molecular Weight 316.15
Formula C15H10BrNO2
CAS Number 79183-37-2
Form Solid
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Thomas M Bridges, et al. Bioorg Med Chem Lett. Heterobiaryl and Heterobiaryl Ether Derived M5 Positive Allosteric Modulators

[2] Thomas M Bridges, et al. Bioorg Med Chem Lett. Chemical Lead Optimization of a Pan Gq mAChR M1, M3, M5 Positive Allosteric Modulator (PAM) Lead. Part II: Development of a Potent and Highly Selective M1 PAM

[3] Thomas M Bridges, et al. J Med Chem. Discovery of the First Highly M5-preferring Muscarinic Acetylcholine Receptor Ligand, an M5 Positive Allosteric Modulator Derived From a Series of 5-trifluoromethoxy N-benzyl Isatins

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Keywords: VU0119498, VU-0119498 supplier, AChR/AChE, inhibitors, activators

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