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Vinorelbine

Cat. No. M3550

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Vinorelbine Structure
Synonym:

KW-2307 base

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50mg USD 240  USD240 Out of stock
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Biological Activity

Vinorelbine (Navelbine) is the first 5´NOR semi-synthetic vinca alkaloid and exerts its activity through the MAPK (p38) pathway with median IC90 and IC50 of 15.5 and 2.3 μM. Vinorelbine (Navelbine) is obtained by semi-synthesis from alkaloids extracted from the rosy periwinkle, Catharanthus roseus. Vinorelbine (Navelbine) is an anti-mitotic chemotherapy agent that is given as a treatment for some types of cancer, including breast cancer and non-small cell lung cancer. In MCF-7 and MDA-MB-468, increased p38 activity was demonstrated following vinorelbine but not doxorubicin treatment, whether vinorelbine was given prior to or simultaneously with doxorubicin. Mitogen-activated protein kinase (MAPK) activity and p53 expression remained unchanged following vinorelbine treatment.

Chemical Information
Molecular Weight 778.93
Formula C45H54N4O8
CAS Number 71486-22-1
Solubility (25°C) DMSO 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Peng Yuan, et al. Eribulin mesilate versus vinorelbine in women with locally recurrent or metastatic breast cancer: A randomised clinical trial

[2] Dongsheng Yue, et al. Erlotinib versus vinorelbine plus cisplatin as adjuvant therapy in Chinese patients with stage IIIA EGFR mutation-positive non-small-cell lung cancer (EVAN): a randomised, open-label, phase 2 trial

[3] Gianni Bisogno, et al. Vinorelbine and continuous low-dose cyclophosphamide as maintenance chemotherapy in patients with high-risk rhabdomyosarcoma (RMS 2005): a multicentre, open-label, randomised, phase 3 trial

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Keywords: Vinorelbine, KW-2307 base supplier, Microtubule, inhibitors, activators

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