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Vinflunine

Cat. No. M3723

All AbMole products are for research use only, cannot be used for human consumption.

Vinflunine Structure
Size Price Availability
5mg USD 140  USD140 Out of stock
10mg USD 260  USD260 Out of stock
50mg USD 795  USD795 Out of stock
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Quality Control & Documentation
Biological Activity

The behavior of vinflunine in routine clinical practice resembles that of the pivotal phase III randomized study. Vinflunine(VFL)-EPR combination is feasible with manageable toxicity. The antitumour activity was promising and supports further evaluation. It underscores a critical function for VFL in cell-cell adhesions of epithelial bladder tumour cells, suggesting a novel molecular mechanism by which VFL may impact upon EMT and metastasis.

Chemical Information
Molecular Weight 816.93
Formula C45H54F2N4O8
CAS Number 162652-95-1
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Castellano D, et al. BMC Cancer. Safety and effectiveness of vinflunine in patients with metastatic transitional cell carcinoma of the urothelial tract after failure of one platinum-based systemic therapy in clinical practice.

[2] Aparicio LA, et al. BMC Cancer. Role of the microtubule-targeting drug vinflunine on cell-cell adhesions in bladder epithelial tumour cells.

[3] Chan S, et al. Cancer Chemother Pharmacol. A phase I clinical and pharmacokinetic study evaluating vinflunine in combination with epirubicin as first-line treatment in metastatic breast cancer.

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Keywords: Vinflunine supplier, Microtubule, inhibitors, activators

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