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Vindesine sulfate (Eldesine, Eldisine, Desacetyl Vinblastine amide, Desacetylvinblastine amide, DAVA, DVA, VDS), a vinca alkaloid derived from Catharanthus roseus, is a potent inhibitor of mitosis with antineoplastic activities. Vindesine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death.
| Molecular Weight | 852 |
| Formula | C43H57N5O11S |
| CAS Number | 59917-39-4 |
| Solubility (25°C) | DMSO 100 mg/mL Water 100 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Michael R Cohen. Nursing. Vindesine tragedy
[2] N Gkbuget, et al. Leuk Lymphoma. Vindesine in the treatment of leukaemia
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