All AbMole products are for research use only, cannot be used for human consumption.
Verucerfont is a corticotropin-releasing factor receptor 1 (CRF1) antagonist with IC50s of ~6.1, >1000 and >1000 nM for CRF1, CRF2, and CRF-BP, respectively.
Biochem Biophys Res Commun. 2020 Apr 30;525(2):326-333.
Spexin as an Anxiety Regulator in Mouse Hippocampus: Mechanisms for Transcriptional Regulation of Spexin Gene Expression by Corticotropin Releasing Factor
Verucerfont purchased from AbMole
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| Animal models | Male Sprague-Dawley rats |
| Formulation | |
| Dosages | 5 mL/kg |
| Administration | oral |
| Molecular Weight | 406.48 |
| Formula | C22H26N6O2 |
| CAS Number | 885220-61-1 |
| Solubility (25°C) | DMSO 77 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related CRFR Products |
|---|
| DMP 696
DMP 696 is a selective corticotropin-releasing hormone receptor 1 (CRHR1) antagonist, used for the treatment of anxiety and depression. |
| Antalarmin
Antalarmin is a selective nonpeptide corticotropin-releasing factor receptor 1 (CRHR1) antagonist with a Ki of 2.7 nM. |
| Antisauvagine-30
Antisauvagine-30 (aSvg-30) is a potent, competitive and selective CRF2 receptor antagonist with Kd values of 1.4 nM and 153.6 nM for mouse CRF2β and rat CRF1 receptors, respectively. |
| NBI-27914 hydrochloride
NBI-27914 (hydrochloride) is a selective Corticotropin-Releasing Factor 1 (CRF1) receptor antagonist with a Ki value of 1.7 nM. |
| K41498 TFA
K41498 TFA is an antisauvagine-30 (aSvg-30) analog and a strongly selective CRF2 receptor antagonist with Ki values of 0.66 nM, 0.62 nM, and 425 nM for human CRF2α, CRF2β, and CRF1 receptors, respectively.K41498 TFA inhibits sauvagine-stimulated cAMP accumulation in hCRF2α/hCRF2β expressing cells. K41498 TFA can be used in hypotension studies. |
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