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Corticotropin-releasing factor (human)

Cat. No. M13936

All AbMole products are for research use only, cannot be used for human consumption.

Corticotropin-releasing factor (human) Structure
Synonym:

Human CRF; Human corticotropin-releasing factor

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Quality Control & Documentation
Biological Activity

Corticotropin-releasing factor human (Human CRF) stimulates the synthesis and secretion of adrenocorticotropin in the anterior pituitary.

Chemical Information
Molecular Weight 4757.45
CAS Number 86784-80-7
Solubility (25°C) Water 25 mg/mL (ultrasonic and adjust pH to 2 with HCl)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] George Liapakis. Editorial: Corticotropin Releasing Factor (CRF) and Its Receptors: From Structure to Function in Health and Disease (Part II)

[2] Efterpi Chouridou, et al. Corticotropin-releasing factor (CRF) system localization in human fetal heart

[3] Limor Regev, et al. Corticotropin releasing factor in neuroplasticity

[4] F M Reis, et al. Putative role of placental corticotropin-releasing factor in the mechanisms of human parturition

[5] N Yasuda, et al. Corticotropin-releasing factor

Related CRFR Products
DMP 696 

DMP 696 is a selective corticotropin-releasing hormone receptor 1 (CRHR1) antagonist, used for the treatment of anxiety and depression.

Antalarmin 

Antalarmin is a selective nonpeptide corticotropin-releasing factor receptor 1 (CRHR1) antagonist with a Ki of 2.7 nM.

Antisauvagine-30

Antisauvagine-30 (aSvg-30) is a potent, competitive and selective CRF2 receptor antagonist with Kd values of 1.4 nM and 153.6 nM for mouse CRF2β and rat CRF1 receptors, respectively.

NBI-27914 hydrochloride 

NBI-27914 (hydrochloride) is a selective Corticotropin-Releasing Factor 1 (CRF1) receptor antagonist with a Ki value of 1.7 nM.

K41498 TFA

K41498 TFA is an antisauvagine-30 (aSvg-30) analog and a strongly selective CRF2 receptor antagonist with Ki values of 0.66 nM, 0.62 nM, and 425 nM for human CRF2α, CRF2β, and CRF1 receptors, respectively.K41498 TFA inhibits sauvagine-stimulated cAMP accumulation in hCRF2α/hCRF2β expressing cells. K41498 TFA can be used in hypotension studies.

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Keywords: Corticotropin-releasing factor (human), Human CRF; Human corticotropin-releasing factor supplier, CRFR, inhibitors, activators

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