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Verubulin hydrochloride

Cat. No. M30904

All AbMole products are for research use only, cannot be used for human consumption.

Verubulin hydrochloride Structure
Synonym:

MPC-6827 hydrochloride

Price and Availability

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Quality Control & Documentation
Biological Activity

Verubulin hydrochloride (MPC-6827 hydrochloride) is a blood brain barrier permeable microtubule-disrupting agent, with potent and broad-spectrum in vitro and in vivo cytotoxic activities. Verubulin hydrochloride (MPC-6827 hydrochloride) exhibits potent anticancer activity in human MX-1 breast and other mouse xenograft cancer models. Verubulin hydrochloride (MPC 6827 hydrochloride) is a promising candidate for the treatment of multiple cancer types.

Chemical Information
Molecular Weight 315.8
Formula C17H18ClN3O
CAS Number 917369-31-4
Form Solid
Solubility (25°C) DMSO 62.5 mg/mL (ultrasonic and warming and heat to 60°C)
Storage 4°C, dry, sealed
References

[1] Anton Lindberg, et al. Front Neurosci. Preliminary Evaluations of [11C]Verubulin: Implications for Microtubule Imaging With PET

[2] Wenlong Li, et al. Bioorg Chem. Discovery of novel quinazolines as potential anti-tubulin agents occupying three zones of colchicine domain

[3] Marc C Chamberlain, et al. J Neurooncol. A phase 2 trial of verubulin for recurrent glioblastoma: a prospective study by the Brain Tumor Investigational Consortium (BTIC)

[4] Katharina Mahal, et al. ChemMedChem. Effects of the tumor-vasculature-disrupting agent verubulin and two heteroaryl analogues on cancer cells, endothelial cells, and blood vessels

[5] Kenneth F Grossmann, et al. J Neurooncol. Phase I trial of verubulin (MPC-6827) plus carboplatin in patients with relapsed glioblastoma multiforme

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Keywords: Verubulin hydrochloride, MPC-6827 hydrochloride supplier, Microtubule, inhibitors, activators

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