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Vardenafil is a selective, orally active, potent inhibitor of phosphodiesterase-5 (PDE5), with an IC50 of 0.7 nM. Vardenafil shows selectivity over PDE1 (180 nM), PDE6 (11 nM), PDE2, PDE3, and PDE4 (>1000 nM). Vardenafil competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Vardenafil can be used for the research of erectile dysfunction.
| Molecular Weight | 488.6 |
| CAS Number | 224785-90-4 |
| Solubility (25°C) | DMSO 25 mg/mL |
| Storage | 2-8°C, protect from light, dry, sealed |
[2] Abdelkader E Ashour, et al. Vardenafil dihydrochloride
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