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Val-cit-PAB-OH is a cathepsin cleavable ADC peptide linker for making MC-Val-Cit-PAB, which is also known as MC-Val-Cit-PAB-OH. MC-Val-Cit-PAB is useful for making ADC (antibody-drug conjugates). The Val-Cit will specifically be cleaved by catepsin B. As this enzyme is only present in the lysosome the ADC payload will be release only in the cell. Azido group will react with DBCO, BCN or other Alkyne group through click chemistry, PEG spacer increases aqueous solubility.
| Molecular Weight | 379.45 |
| Formula | C18H29N5O4 |
| CAS Number | 159857-79-1 |
| Solubility (25°C) | DMSO ≥ 90 mg/mL |
| Storage | 2-8°C, protect from light, dry, sealed |
| Related ADC Linker Products |
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| Sulfo-LC-SPDP sodium
Sulfo-LC-SPDP sodium is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
| DBCO-Maleimide
DBCO-Maleimide is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-Maleimide is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. |
| SPDB-sulfo
SPDB-sulfo is a glutathione cleavable ADC linker used for the antibody-drug conjugate (ADCs) . |
| Tr-PEG5-OH
Tr-PEG5-OH is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
| DBCO-amine
DBCO-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
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