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SPDP crosslinker, or SPDP NHS ester, is a cleavable, water insoluble, amino and thiol (sulfhydryl) reactive heterobifunctional protein crosslinker. The SPDP Crosslinker is useful in making antibody drug conjugates (ADCs).
*The compound is unstable in solutions, freshly prepared is recommended
| Molecular Weight | 312.36 |
| Formula | C12H12N2O4S2 |
| CAS Number | 68181-17-9 |
| Solubility (25°C) | DMSO ≥ 100 mg/mL |
| Storage | -20°C, protect from light, sealed |
| Related ADC Linker Products |
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| 8-Azido-3,6-dioxaoctanoic Acid Cyclohexylamine Salt
8-Azido-3,6-dioxaoctanoic Acid Cyclohexylamine Salt is a azido-modified PEG2 acid, can be used as a click chemistry reagent. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups. |
| DOTA-NHS-ester
DOTA-NHS-ester is a linker for affibody molecules and is applied in small animals PET. DOTA-NHS-ester can be used to label radiotherapeutic agents or imaging probes for the detection of tumors. |
| Sulfo-LC-SPDP sodium
Sulfo-LC-SPDP sodium is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
| DBCO-Maleimide
DBCO-Maleimide is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-Maleimide is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. |
| SPDB-sulfo
SPDB-sulfo is a glutathione cleavable ADC linker used for the antibody-drug conjugate (ADCs) . |
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