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SPDP Crosslinker

Cat. No. M10401
SPDP Crosslinker Structure
Synonym:

SPDP NHS ester

Size Price Availability Quantity
10mg USD 54  USD54 In stock
50mg USD 140  USD140 In stock
100mg USD 210  USD210 In stock
500mg USD 600  USD600 In stock
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Quality Control & Documentation
Biological Activity

SPDP crosslinker, or SPDP NHS ester, is a cleavable, water insoluble, amino and thiol (sulfhydryl) reactive heterobifunctional protein crosslinker. The SPDP Crosslinker is useful in making antibody drug conjugates (ADCs).

*The compound is unstable in solutions, freshly prepared is recommended

Chemical Information
Molecular Weight 312.36
Formula C12H12N2O4S2
CAS Number 68181-17-9
Solubility (25°C) DMSO ≥ 100 mg/mL
Storage -20°C, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Subha Karumuthil-Melethil, et al. J Immunol. Dendritic cell-directed CTLA-4 engagement during pancreatic beta cell antigen presentation delays type 1 diabetes

[2] Sune Lobedanz, et al. Proc Natl Acad Sci U S A. A periplasmic coiled-coil interface underlying TolC recruitment and the assembly of bacterial drug efflux pumps

[3] V Singh, et al. Indian J Exp Biol. Effect of lysine residue modification of ovine luteinizing hormone by heterobifunctional crosslinking reagent SPDP on subunit-subunit association, receptor binding and biological activity

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Keywords: SPDP Crosslinker, SPDP NHS ester supplier, ADC Linker, inhibitors, activators


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