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Mc-Val-Cit-PAB is a peptide linker molecule used in the synthesis of antibody-drug conjugates (ADCs). It contains a maleimidocaproyl (Mc) group that can be conjugated to an antibody and a p-aminobenzyl (PAB) spacer that allows the peptide to be linked to active compounds, such as anticancer agents. Mc-Val-Cit-PAB is cleaved in vivo by cathepsin B, a protease highly expressed in cancer cells, which confers specificity of the ADC to cancer cells.
| Molecular Weight | 572.65 |
| Formula | C28H40N6O7 |
| CAS Number | 159857-80-4 |
| Solubility (25°C) | DMSO ≥ 90 mg/mL |
| Storage | 2-8°C, protect from light, sealed |
| Related ADC Linker Products |
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| Sulfo-LC-SPDP sodium
Sulfo-LC-SPDP sodium is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
| DBCO-Maleimide
DBCO-Maleimide is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-Maleimide is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. |
| SPDB-sulfo
SPDB-sulfo is a glutathione cleavable ADC linker used for the antibody-drug conjugate (ADCs) . |
| Tr-PEG5-OH
Tr-PEG5-OH is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
| DBCO-amine
DBCO-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
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