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Mc-Val-Cit-PAB

Cat. No. M10409
Mc-Val-Cit-PAB Structure
Synonym:

MC-Val-Cit-PAB-OH

Size Price Availability Quantity
50mg USD 130  USD130 In stock
100mg USD 185  USD185 In stock
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Quality Control & Documentation
Biological Activity

Mc-Val-Cit-PAB is a peptide linker molecule used in the synthesis of antibody-drug conjugates (ADCs). It contains a maleimidocaproyl (Mc) group that can be conjugated to an antibody and a p-aminobenzyl (PAB) spacer that allows the peptide to be linked to active compounds, such as anticancer agents. Mc-Val-Cit-PAB is cleaved in vivo by cathepsin B, a protease highly expressed in cancer cells, which confers specificity of the ADC to cancer cells.

Chemical Information
Molecular Weight 572.65
Formula C28H40N6O7
CAS Number 159857-80-4
Solubility (25°C) DMSO ≥ 90 mg/mL
Storage 2-8°C, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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Boc-Gly-Gly-Phe-Gly-OH TFA

Boc-Gly-Gly-Phe-Gly-OH TFA, a self-assembly of N- and C-protected tetrapeptide, is a protease cleavable linker used for the antibody-drug conjugate (ADC).

Boc-Gly-Gly-Phe-Gly-OH

Boc-Gly-Gly-Phe-Gly-OH, a self-assembly of N- and C-protected tetrapeptide, is a protease cleavable linker used for the antibody-drug conjugate (ADC).

Fomc-Gly-Gly-Phe-Gly-OH

Fomc-Gly-Gly-Phe-Gly-OH can be used as an intermediate in the synthesis of ADC dual-drug-linker.

Mc-Gly-Gly-Phe-Gly-PAB-OH

Mc-Gly-Gly-Phe-Gly-PAB-OH (Mc-GGFG-PAB-OH) is a cleavable ADC linker used for antibody-drug conjugates (ADCs).

  Catalog
Abmole Inhibitor Catalog




Keywords: Mc-Val-Cit-PAB, MC-Val-Cit-PAB-OH supplier, ADC Linker, inhibitors, activators


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