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Vacquinol-1

Cat. No. M9175
Vacquinol-1 Structure
Synonym:

NSC13316

Size Price Availability
5mg USD 430  USD430 1-2 Weeks
10mg USD 780  USD780 1-2 Weeks
25mg USD 1425  USD1425 1-2 Weeks
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Quality Control & Documentation
Biological Activity

Vacquinol-1 is an MKK4 activator, which rapidly and selectively induces glioma cell death.

Chemical Information
Molecular Weight 426
Formula C25H22N2O2
CAS Number 5428-80-8
Solubility (25°C) DMSO 70 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Dongoh Kwak, et al. Glioblastoma cytotoxicity conferred through dual disruption of endolysosomal homeostasis by Vacquinol-1

[2] Shu-Lan Sun, et al. Vacquinol‑1 induces apoptosis in hepatocellular carcinoma cell

[3] Jonatan Ahlstedt, et al. Evaluating vacquinol-1 in rats carrying glioblastoma models RG2 and NS1

[4] Philip Sander, et al. Vacquinol-1 inducible cell death in glioblastoma multiforme is counter regulated by TRPM7 activity induced by exogenous ATP

[5] Lars G J Hammarstrm, et al. The Oncolytic Efficacy and in Vivo Pharmacokinetics of [2-(4-Chlorophenyl)quinolin-4-yl](piperidine-2-yl)methanol (Vacquinol-1) Are Governed by Distinct Stereochemical Features

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Keywords: Vacquinol-1, NSC13316 supplier, JNK, inhibitors, activators

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