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Vacquinol-1

Cat. No. M9175
Vacquinol-1 Structure
Synonym:

NSC13316

Size Price Availability
10mg USD 180  USD180 Out of stock
25mg USD 350  USD350 Out of stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Vacquinol-1 is an MKK4 activator, which rapidly and selectively induces glioma cell death.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 426
Formula C25H22N2O2
CAS Number 5428-80-8
Purity >98%
Solubility DMSO 70 mg/mL
Storage at -20°C
References

[1] Dongoh Kwak, et al. Glioblastoma cytotoxicity conferred through dual disruption of endolysosomal homeostasis by Vacquinol-1

[2] Shu-Lan Sun, et al. Vacquinol‑1 induces apoptosis in hepatocellular carcinoma cell

[3] Jonatan Ahlstedt, et al. Evaluating vacquinol-1 in rats carrying glioblastoma models RG2 and NS1

[4] Philip Sander, et al. Vacquinol-1 inducible cell death in glioblastoma multiforme is counter regulated by TRPM7 activity induced by exogenous ATP

[5] Lars G J Hammarstrm, et al. The Oncolytic Efficacy and in Vivo Pharmacokinetics of [2-(4-Chlorophenyl)quinolin-4-yl](piperidine-2-yl)methanol (Vacquinol-1) Are Governed by Distinct Stereochemical Features

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Keywords: Vacquinol-1, NSC13316 supplier, JNK, inhibitors

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