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UNC2025 hydrochloride is a potent, ATP-competitive, and highly orally active Mer/Flt3 inhibitor with IC50 values of 0.74 nM and 0.8 nM, respectively. UNC2025 hydrochloride is >45-fold selectivity for MERTK relative to Axl (IC50= 122 nM; Ki = 13.3 nM). UNC2025 hydrochloride exhibits an excellent PK properties, and can be used for the investigation of acute leukemia.
| Molecular Weight | 513.12 |
| CAS Number | 2070015-17-5 |
| Solubility (25°C) | Water 55 mg/mL DMSO 10 mg/mL |
| Storage | 2-8°C, dry, sealed |
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