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Ubrogepant

Cat. No. M10894
Ubrogepant  Structure
Synonym:

MK-1602

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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Ubrogepant (MK-1602) is a novel oral calcitonin gene-associated peptide receptor (CGRP) antagonist with the potential to be used in acute migraine studies.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 549.54
Formula C29H26F3N5O3
CAS Number 1374248-77-7
Purity >99%
Solubility DMSO ≥ 200 mg/mL
Storage at -20°C
References

[1] No authors listed. Expert Opin Pharmacother. Ubrogepant

[2] No authors listed. Expert Opin Pharmacother. Ubrogepant

[3] Martina Curto, et al. Expert Opin Pharmacother. Ubrogepant for the treatment of migraine

[4] David W Dodick, et al. N Engl J Med. Ubrogepant for the Treatment of Migraine

[5] Richard B Lipton, et al. JAMA. Effect of Ubrogepant vs Placebo on Pain and the Most Bothersome Associated Symptom in the Acute Treatment of Migraine: The ACHIEVE II Randomized Clinical Trial

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Keywords: Ubrogepant , MK-1602 supplier, CGRP Receptor, inhibitors

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