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Adrenomedullin (AM) (22-52), human

Cat. No. M53900
Adrenomedullin (AM) (22-52), human Structure
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Biological Activity

Adrenomedullin (AM) (22-52), human is an adrenomedullin receptor antagonist, and also antagonizes the calcitonin generelated peptide (CGRP) receptor in the hindlimb vascular bed of the cat.

Chemical Information
Molecular Weight 3576.04
Formula C159H252N46O48
CAS Number 159899-65-7
Form Solid
Solubility (25°C) DMSO 90 mg/mL
Water 30 mg/mL
Storage -20°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Related CGRP Receptor Products
Adrenomedullin (16-31), human

Adrenomedullin (16-31), human is amino acid residues 16-31 fragment of human adrenomedullin (hADM).

α-CGRP(human)

α-CGRP(human) is a regulatory neuropeptide of 37 amino acids.

Calcitonin Gene Related Peptide (CGRP) II, rat

Calcitonin Gene Related Peptide (CGRP) II, rat, a CGRP receptor activator, is a potent and long-lasting vasodilator.

Adrenomedullin (11-50), rat

Adrenomedullin (11-50), rat is the C-terminal fragment (11-50) of rat adrenomedullin.

α-CGRP (mouse, rat)

α-CGRP (mouse, rat), a neuropeptide (calcitonin gene-related peptide (CGRP)) mainly expressed in neuromuscular junction, is a potent vasodilator.

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