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Tucatinib hemiethanolate

Cat. No. M14142
Tucatinib hemiethanolate Structure
Synonym:

Irbinitinib hemiethanolate; ARRY-380 hemiethanolate; ONT-380 hemiethanolate

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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Tucatinib (Irbinitinib) hemiethanolate is a potent, orally active and selective HER2 inhibitor with an IC50 of 8 nM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 503.57
Formula
CAS Number 1429755-56-5
Purity >99%
Solubility DMSO 90 mg/mL
Storage at -20°C
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Keywords: Tucatinib hemiethanolate, Irbinitinib hemiethanolate; ARRY-380 hemiethanolate; ONT-380 hemiethanolate supplier, EGFR/HER2, inhibitors

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