All AbMole products are for research use only, cannot be used for human consumption.
Trimetazidine is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC50 of 75 nM, which can inhibit β-oxidation of free fatty acid (FFA). Trimetazidine is an effective antianginal agent and a cytoprotective drug, has anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties. Trimetazidine triggers autophagy. Trimetazidine is also a 3-hydroxyacyl-CoA dehydrogenase (HADHA) inhibitor.
| Molecular Weight | 266.34 |
| CAS Number | 5011-34-7 |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage | 2-8°C, protect from light, sealed |
[1] Dvid Pintr, et al. eNeuro. Trimetazidine Use in Parkinson's Disease: Is It a Resolved Problem?
[2] Mario Marzilli, et al. Int J Cardiol. Trimetazidine in cardiovascular medicine
[3] Agustn Ciapponi, et al. Cochrane Database Syst Rev. WITHDRAWN: Trimetazidine for stable angina
[4] I V Zhirov, et al. Kardiologiia. [Trimetazidine in the Treatment of Chronic HeartFailure]
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