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Triacsin C (WS 1228A) is a natural intracellular long-chain acyl-CoA synthetases (ACSL) inhibitor. Triacsin C inhibits lipid synthesis and cell proliferation in Raji lymphoma cells. Triacsin C (0-16 μM; 41 h) inhibits parasite fatty acyl-coenzyme A synthetases, and reduces CpACS1 and CpACS2 enzymes activities with IC50s of 3.70 μM and 2.32 μM, respectively, with Ki values of 595 nM and 106 nM, respectively.
Triacsin C induces apoptosis in cancer cell lines and inhibits human lung cancer cell xenograft tumor growth in mice. Triacsin C (8-15 mg/kg/d; p.o.; 1 week) shows anticryptosporidial efficacy and improves Cryptosporidium parvum infection by targeting parasite fatty acyl-coenzyme A synthetases. Triacsin C (10 mg/kg/d; p.o.; 2 months) exhibits anti-atherosclerotic activity in aortic atherosclerosis LDLR-/- mice.
| Molecular Weight | 207.27 |
| Formula | C11H17N3O |
| CAS Number | 76896-80-5 |
| Form | Solid |
| Solubility (25°C) | DMSO 3 mg/mL |
| Storage | -20°C, dry, sealed |
[1] Hagan, et al. Eur J Pharmacol. Stimulation of 5-HT1B receptors causes hypothermia in the rat.
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