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Trazodone hydrochloride

Cat. No. M6027
Trazodone hydrochloride Structure
Synonym:

AF-1161; KB-831

Size Price Availability Quantity
100mg USD 75  USD75 In stock
500mg USD 100  USD100 In stock
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Quality Control & Documentation
Biological Activity

Trazodone HCl is an antidepressant belonging to the class of serotonin receptor antagonists and reuptake inhibitors for treatment of anxiety disorders.

Chemical Information
Molecular Weight 408.32
Formula C19H22ClN5O.HCl
CAS Number 25332-39-2
Form Solid
Solubility (25°C) 4 mg/mL warmed in DMSO
Storage 2-8°C
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] McIntyre IM, et al. Forensic Sci Int. Postmortem distribution of trazodone concentrations.

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Keywords: Trazodone hydrochloride, AF-1161; KB-831 supplier, 5-HT Receptor, inhibitors, activators


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