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Torilin

Cat. No. M42742
Torilin Structure
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Biological Activity

Torilin is a sesquiterpene with antimicrobial, anticancer, and anti-inflammatory properties.

Chemical Information
Molecular Weight 376.49
Formula C22H32O5
CAS Number 13018-10-5
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Mehari Endale et al. Mediators Inflamm. Torilin Inhibits Inflammation by Limiting TAK1-Mediated MAP Kinase and NF- κ B Activation

[2] Mehari Endale et al. Int Immunopharmacol. Torilin ameliorates type II collagen-induced arthritis in mouse model of rheumatoid arthritis

[3] Cheong-Yong Yun et al. Planta Med. Torilin from Torilis japonica inhibits melanin production in alpha-melanocyte stimulating hormone-activated B16 melanoma cells

[4] M S Kim et al. Oncol Rep. Anti-invasive activity of torilin, a sesquiterpene compound isolated from Torilis japonica

[5] H Chikamatsu et al. Tetrahedron. Structure of torilin

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