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Tomatine

Cat. No. M19378

All AbMole products are for research use only, cannot be used for human consumption.

Tomatine Structure

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Biological Activity

Tomatine elicits neurotoxicity in RIP1 kinase and caspase-independent manner. Tomatine promotes the upregulation of nuclear apoptosis inducing factor (AIF) in neuroblastoma cells. Tomatine also inhibits 20S proteasome activity.

Chemical Information
Molecular Weight 1034.19
Formula C50H83NO21
CAS Number 17406-45-0
Form Solid
Solubility (25°C) DMSO 100 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Christian Bailly. Steroids. The steroidal alkaloids α-tomatine and tomatidine: Panorama of their mode of action and pharmacological properties

[2] Hailun Wu, et al. Fitoterapia. α-Tomatine, a novel early-stage autophagy inhibitor, inhibits autophagy to enhance apoptosis via Beclin-1 in Skov3 cells

[3] Masaru Nakayasu, et al. Plant Physiol. Tomato roots secrete tomatine to modulate the bacterial assemblage of the rhizosphere

[4] Simona Serrat, et al. Int J Mol Sci. Tomatine Displays Antitumor Potential in In Vitro Models of Metastatic Melanoma

[5] Masaru Nakayasu, et al. Plant Cell Physiol. Identification of α-Tomatine 23-Hydroxylase Involved in the Detoxification of a Bitter Glycoalkaloid

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Keywords: Tomatine supplier, Proteasome, inhibitors, activators

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