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Tiotropium Bromide

Cat. No. M6016
Tiotropium Bromide   Structure
Synonym:

Tiopropium

Size Price Availability Quantity
50mg USD 120  USD120 In stock
100mg USD 220  USD220 In stock
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Biological Activity

Tiotropium Bromide is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 472.42
Formula C19H22BrNO4S2
CAS Number 136310-93-5
Purity 99.40%
Solubility 30 mg/mL in DMSO
Storage at -20°C
References

[1] Bosnjak B, et al. Pulm Pharmacol Ther. Tiotropium bromide inhibits relapsing allergic asthma in BALB/c mice.

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Keywords: Tiotropium Bromide , Tiopropium supplier, AChR/AChE, inhibitors

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