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Cat. No. M3315
Thiabendazole Structure


Size Price Availability Quantity
500mg USD 40  USD40 In stock
1g USD 50  USD50 In stock
5g USD 95  USD95 In stock
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Quality Control & Documentation
Biological Activity

Thiabendazole inhibites the mitochondrial helminth-specific enzyme, fumarate reductase, with possible interaction with endogenous quinone.A benzimidazole derivative with anthelminthic property. Thiabendazole inhibits the helminth-specific mitochondrial enzyme fumarate reductase, thereby inhibiting the citric acid cycle, mitochondrial respiration and subsequent production of ATP, ultimately leading to helminth’s death.

Chemical Information
Molecular Weight 201.25
Formula C10H7N3S
CAS Number 148-79-8
Form Solid
Solubility (25°C) DMSO 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] V K Shormanov, et al. Determination of thiabendazole in the conditions of chemical and toxicological analysis of biomaterial

[2] Xiong-Xin Peng, et al. Highly sensitive and rapid detection of thiabendazole residues in oranges based on a luminescent Tb 3+-functionalized MOF

[3] Cesar Henriquez-Camacho, et al. Ivermectin versus albendazole or thiabendazole for Strongyloides stercoralis infection

[4] Rafael Igual-Adell, et al. Efficacy and safety of ivermectin and thiabendazole in the treatment of strongyloidiasis

[5] H J Robinson, et al. Thiabendazole: toxicological, pharmacological and antifungal properties

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Keywords: Thiabendazole, 2-(4-Thiazolyl)benzimidazole supplier, Mitochondrial Related, inhibitors, activators

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