Thiabendazole inhibites the mitochondrial helminth-specific enzyme, fumarate reductase, with possible interaction with endogenous quinone.A benzimidazole derivative with anthelminthic property. Thiabendazole inhibits the helminth-specific mitochondrial enzyme fumarate reductase, thereby inhibiting the citric acid cycle, mitochondrial respiration and subsequent production of ATP, ultimately leading to helminth’s death.
|Solubility (25°C)||DMSO 30 mg/mL|
Powder -20°C 3 years ; 4°C 2 years
In solvent -80°C 6 months ; -20°C 1 month
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Related Mitochondrial Related Products|
Ferulenol is a sesquiterpene-based coumarin derivative isolated and purified from Ferula vesceritensis that causes inhibition of oxidative phosphorylation. At low concentrations, it can inhibit ATP synthesis by inhibiting adenine nucleotide translocase, and has pro-oxidant and anti-cancer activities. In addition, Ferulenol also induces specific inhibition of succinate ubiquinone reductase without altering the succinate dehydrogenase activity of complex II. Ferulenol can be used to study the physiological role of mitochondrial complex II and electron transport mechanisms.
T0467 is a potential PINK1-Parkin signaling activator that activates mitochondrial parkin translocation in a PINK1-dependent manner, but does not induce mitochondrial aggregation of PINK1 in dopaminergic neurons. It can be used in the study of Parkinson's disease and related disorders.
Genistein 8-c-glucoside (G8CG) is a glucoside. Genistein 8-c-glucoside induces mitochondrial membrane depolarization and induces apoptosis.
1-Hexanol is a tertiary alcohol that also acts as a surfactant and uncouples mitochondrial respiration by a nonprotonic mechanism.
Petasin (PT) is a naturally occurring sesquiterpene ester derived from plants and is also a potent mitochondrial electron transport chain complex I (ETCC1) inhibitor with broad-spectrum antitumor activity.
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