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TH5427 is a promising, targeted inhibitor that can be used to further study NUDT5 activity and ADP-ribose metabolism. TH5427, blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells. NUDT5 is recently identified as a rheostat of hormone-dependent gene regulation and proliferation in breast cancer cells.
| Molecular Weight | 491.33 |
| Formula | C20H20Cl2N8O3 |
| CAS Number | 2253744-56-6 |
| Form | Solid |
| Solubility (25°C) | DMSO 5 mg/mL (ultrasonic and warming and heat to 60°C) |
| Storage | 4°C, protect from light |
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