Certificate of Analysis
| Product Name: | TH5427 |
| Catalog Number: | M29452 |
| CAS Number: | 2253744-56-6 |
Physical and Chemical Properties
| Formula: | C20H20Cl2N8O3 |
| Molecular Weight: | 491.33 |
| Form: | Solid |
| Solubility: | DMSO 5 mg/mL (ultrasonic and warming and heat to 60°C) |
| Storage: | 4°C, protect from light |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | ≥99.0% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | TH5427 is a promising, targeted inhibitor that can be used to further study NUDT5 activity and ADP-ribose metabolism. TH5427, blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells. NUDT5 is recently identified as a rheostat of hormone-dependent gene regulation and proliferation in breast cancer cells. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |