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TFCA

Cat. No. M8590
TFCA Structure
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

TFCA is a Liver X receptor α (LXRα) antagonist that reduces lipid accumulation and fatty liver in mice. Apparently TFCA binds to the LXRα ligand binding domain and induces interaction with NCoR corepressor.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 351.32
Formula C18H16F3NO3
CAS Number 895700-18-2
Purity >98%
Solubility DMSO 25 mg/mL
Storage at -20°C
References

[1] Woo-Cheol Sim, et al. J Pharmacol Exp Ther . Cinnamamides, Novel Liver X Receptor Antagonists that Inhibit Ligand-Induced Lipogenesis and Fatty Liver

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