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Tegaserod maleate

Cat. No. M5992
Tegaserod maleate Structure
Synonym:

SDZ-HTF-919; HTF-919

Size Price Availability Quantity
10mg USD 115  USD115 In stock
50mg USD 360  USD360 In stock
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Quality Control & Documentation
Biological Activity

Tegaserod maleate is a partial agonist of the 5-HT4 receptor; stimulates the peristaltic reflex and accelerates gastrointestinal transit.

Chemical Information
Molecular Weight 417.46
Formula C20H27N5O5
CAS Number 189188-57-6
Solubility (25°C) 35 mg/mL in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Higgins DL, et al. Naunyn Schmiedebergs Arch Pharmacol. The inability of tegaserod to affect platelet aggregation and coronary artery tone at supratherapeutic concentrations.

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Keywords: Tegaserod maleate, SDZ-HTF-919; HTF-919 supplier, 5-HT Receptor, inhibitors, activators


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