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TD-165 is a PROTAC-based cereblon (CRBN) degrader. TD-165 comprises a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group. TD-165 (0.1-10 μM; 24 hours) leads to a concentration-dependent decrease in the level of CRBN proteins in HEK293T cells.
| Molecular Weight | 870.07 |
| Formula | C46H59N7O8S |
| CAS Number | 2305936-56-3 |
| Solubility (25°C) | DMSO 45 mg/mL |
| Storage | -20°C, protect from light, sealed |
| Related PROTAC Products |
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| ML 2-14
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| GDC-2992
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| Setidegrasib
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| PROTAC HK2 Degrader-1
PROTAC HK2 Degrader-1 is a PROTAC consisting of Lonidamine as a target protein Hexokinase 2 (HK2) inhibitor and Thalidomide as a CRBN ligand-linked PROTAC. PROTAC HK2 Degrader-1 selectively inhibits the proliferation of breast cancer cells by forming a ternary complex through the ubiquitin-proteasome system to degrade Hexokinase 2 (HK2) protein leading to mitochondrial damage and cell death. |
| ZXH-4-130 TFA
ZXH-4-130 TFA is a highly potent and selective degrader of CRBN. ZXH-4-130 is a CRBN-VHL compound (hetero-PROTAC). |
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