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TCMDC-135051

Cat. No. M21393

All AbMole products are for research use only, cannot be used for human consumption.

TCMDC-135051  Structure

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Quality Control & Documentation
Biological Activity

TCMDC-135051 is a highly selective and potent inhibitor of the protein kinase PfCLK3 with low off-target toxicity.TCMDC-135051 prevents trophozoite to lytic transition, disrupts transcription and reduces transmission to mosquito vectors.TCMDC-135051 has antiparasitic activity (EC50=320 nM).

Chemical Information
Molecular Weight 471.59
Formula C29H33N3O3
CAS Number 2413716-15-9
Solubility (25°C) DMSO ≥ 200 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Christopher Swale, et al. Sci Transl Med. Altiratinib blocks Toxoplasma gondii and Plasmodium falciparum development by selectively targeting a spliceosome kinase

[2] Amit Mahindra, et al. J Med Chem. Development of Potent Pf CLK3 Inhibitors Based on TCMDC-135051 as a New Class of Antimalarials

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  Catalog
Abmole Inhibitor Catalog




Keywords: TCMDC-135051 supplier, inhibitors, activators

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