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TB5

Cat. No. M8791

All AbMole products are for research use only, cannot be used for human consumption.

TB5 Structure

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Quality Control & Documentation
Biological Activity

TB5 is a potent and selective reversible inhibitor of monoamine oxidase B (MAOB) with a Ki value of 110 nM. A reversible inhibitor should have an advantage over irreversible inhibitors such as selegiline in limiting side effects. Parallel artificial membrane permeation (PAMPA) assays indicated TB5 should be able to cross the blood–brain barrier. TB5 was found nontoxic to cells.

Chemical Information
Molecular Weight 336.25
Formula C15H14BrNOS
CAS Number 948841-07-4
Solubility (25°C) DMSO: 2 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Pauline Arnaud, et al. Cooperative Mechanism of ADAMTS/ ADAMTSL and Fibrillin-1 in the Marfan Syndrome and Acromelic Dysplasias

[2] Zachary Konkel, et al. Draft Genome Sequence of the Termite-Associated "Cuckoo Fungus," Athelia ( Fibularhizoctonia) sp. TMB Strain TB5

[3] Chengjun Sun, et al. Separation in genetic pathogenesis of mutations in FBN1-TB5 region between autosomal dominant acromelic dysplasia and Marfan syndrome

[4] Sayyed Saeed Moosavi, et al. Phenological, morpho-physiological and proteomic responses of Triticum boeoticum to drought stress

[5] Stuart A Cain, et al. Fibrillin-1 mutations causing Weill-Marchesani syndrome and acromicric and geleophysic dysplasias disrupt heparan sulfate interactions

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Keywords: TB5 supplier, inhibitors, activators

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