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Tavilermide

Cat. No. M14581
Tavilermide Structure
Synonym:

MIM-D3

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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Tavilermide is a selective, partial agonist of TrkA, or a nerve growth factor (NGF) mimetic.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 580.54
Formula
CAS Number 263251-78-1
Purity >99%
Solubility NH4OH : 50 mg/mL (ultrasonic and adjust pH to 10 with NH4OH)
Storage at -20°C
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  Catalog
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Keywords: Tavilermide, MIM-D3 supplier, Trk, inhibitors

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