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Taminadenant

Cat. No. M28199

All AbMole products are for research use only, cannot be used for human consumption.

Taminadenant Structure
Synonym:

NIR178; PBF509

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Quality Control & Documentation
Biological Activity

Taminadenant (NIR178; PBF509) is a highly potent and orally active adenosine A2A receptor (A2AR) antagonist. Taminadenant can antagonize A2AR agonist-mediated cAMP accumulation and impedance responses with KB values of 72.8 nM and 8.2 nM, respectively. Taminadenant reverses motor impairments in several rat models of movement disorders, including catalepsy, tremor, and hemiparkinsonism. Taminadenant can also inhibit tumor growth when combined with Spartalizumab. Taminadenant reactivate the antitumor immune response.

Chemical Information
Molecular Weight 306.12
Formula C10H8BrN7
CAS Number 1337962-47-6
Form Solid
Solubility (25°C) DMSO 100 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Dung-Tsa Chen, et al. Cancers (Basel). Early Adverse Event Derived Biomarkers in Predicting Clinical Outcomes in Patients with Advanced Non-Small Cell Lung Cancer Treated with Immunotherapy

[2] Alberto A Chiappori, et al. Clin Cancer Res. Phase I Study of Taminadenant (PBF509/NIR178), an Adenosine 2A Receptor Antagonist, with or without Spartalizumab (PDR001), in Patients with Advanced Non-Small Cell Lung Cancer

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Keywords: Taminadenant, NIR178; PBF509 supplier, Adenosine Receptor, inhibitors, activators

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