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TAME hydrochloride is an inhibitor of anaphase-promoting complex/cyclosome (APC/C or APC), which binds to APC/C and prevents its activation by Cdc20 and Cdh1, produces mitotic arrest. TAME hydrochloride is not cell permeable.
| Molecular Weight | 378.87 |
| Formula | C14H23ClN4O4S |
| CAS Number | 1784-03-8 |
| Form | Solid |
| Solubility (25°C) | DMSO 155 mg/mL (ultrasonic) Water ≥ 100 mg/mL |
| Storage | -20°C, dry, sealed |
[5] S Fujii, et al. J Biochem. New synthetic inhibitors of chymotrypsin
| Related APC Products |
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| Apcin-A
Apcin-A, an Apcin derivative, is an anaphase-promoting complex (APC) inhibitor. |
| Apcin-A monohydrochloride
Apcin-A monohydrochloride, an Apcin derivative, is an anaphase-promoting complex (APC) inhibitor. |
| proTAME
proTAME, a cell-permeable proagent form of TAME, is an anaphase promoting complex/cyclosome (APC/C) inhibitor. proTAME causes cell cycle arrest in metaphase. |
| Apcin
Apcin, a ligand of Cdc20, is a potent and competitive anaphase-promoting complex/cyclosome (APC/C(Cdc20)) E3 ligase activity inhibitor. Apcin competitively inhibits APC/C-dependent ubiquitylation by binding to Cdc20 and preventing substrate recognition. Apcin is a cdc20 inhibitor; inhibits Cdc20-substrate interaction. |
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