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Apcin is a cdc20 inhibitor; inhibits Cdc20-substrate interaction. Apcin blocks substrate-mediated Cdc20 loading onto the anaphase-promoting complex (APC). Apcin inhibits APC-dependent ubiquitylation. Prolongs mitotic duration in RPE1 cells in combination with proTAME (prodrug of TAME (Cat.No. 4506)) in vitro. Apcin occupes the D-box-binding pocket on the side face of the WD40-domain and can prolong mitosis.
| Molecular Weight | 438.65 |
| Formula | C13H14Cl3N7O4 |
| CAS Number | 300815-04-7 |
| Form | Solid |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related APC Products |
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| Apcin-A
Apcin-A, an Apcin derivative, is an anaphase-promoting complex (APC) inhibitor. |
| Apcin-A monohydrochloride
Apcin-A monohydrochloride, an Apcin derivative, is an anaphase-promoting complex (APC) inhibitor. |
| TAME hydrochloride
TAME hydrochloride is an inhibitor of anaphase-promoting complex/cyclosome (APC/C or APC), which binds to APC/C and prevents its activation by Cdc20 and Cdh1, produces mitotic arrest. TAME hydrochloride is not cell permeable. |
| proTAME
proTAME, a cell-permeable proagent form of TAME, is an anaphase promoting complex/cyclosome (APC/C) inhibitor. proTAME causes cell cycle arrest in metaphase. |
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