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Taltobulin

Cat. No. M13693

All AbMole products are for research use only, cannot be used for human consumption.

Taltobulin Structure
Synonym:

HTI-286; SPA-110

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Quality Control & Documentation
Biological Activity

Taltobulin (HTI-286), a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Taltobulin inhibits the polymerization of purified tubulin, disrupts microtubule organization in cells, and induces mitotic arrest, as well as apoptosis.

Chemical Information
Molecular Weight 473.65
CAS Number 228266-40-8
Solubility (25°C) DMSO ≥ 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jiraborrirak Charoenpattarapreeda, et al. Angew Chem Int Ed Engl. Expeditious Total Synthesis of Hemiasterlin through a Convergent Multicomponent Strategy and Its Use in Targeted Cancer Therapeutics

[2] Norma Flores-Holgun, et al. BMC Res Notes. Conceptual DFT as a chemoinformatics tool for the study of the Taltobulin anticancer peptide

[3] Raymond J Andersen. Biochem Pharmacol. Sponging off nature for new drug leads

[4] Chuansheng Niu, et al. Bioorg Med Chem Lett. Absolute configurations of tubulin inhibitors taltobulin (HTI-286) and HTI-042 characterized by X-ray diffraction analysis and NMR studies

[5] Yogesh-K Vashist, et al. World J Gastroenterol. Inhibition of hepatic tumor cell proliferation in vitro and tumor growth in vivo by taltobulin, a synthetic analogue of the tripeptide hemiasterlin

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Keywords: Taltobulin, HTI-286; SPA-110 supplier, Microtubule, inhibitors, activators

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