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Taccalonolide B

Cat. No. M38931

All AbMole products are for research use only, cannot be used for human consumption.

Taccalonolide B Structure

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Biological Activity

Taccalonolide B is microtubule stabilizer. Taccalonolide B is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug-resistance protein (MRP7). Taccalonolide B inhibits growth of SK-OV-3 cells with an IC50 of 208 nM.

Chemical Information
Molecular Weight 660.71
Formula C34H44O13
CAS Number 108885-69-4
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Hui Tian et al. Artif Cells Nanomed Biotechnol. Anti-hepatoma effect of taccalonolide A through suppression of sonic hedgehog pathway

[2] Lin Du et al. J Nat Prod. Identification of C-6 as a New Site for Linker Conjugation to the Taccalonolide Microtubule Stabilizers

[3] Antonius R B Ola et al. J Nat Prod. Taccalonolide Microtubule Stabilizers Generated Using Semisynthesis Define the Effects of Mono Acyloxy Moieties at C-7 or C-15 and Disubstitutions at C-7 and C-25

[4] Jing Li et al. J Nat Prod. Hydrolysis reactions of the taccalonolides reveal structure-activity relationships

[5] Jiangnan Peng et al. J Med Chem. Identification and biological activities of new taccalonolide microtubule stabilizers

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Keywords: Taccalonolide B supplier, Microtubule, inhibitors, activators

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