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T-1095 

Cat. No. M29219
T-1095  Structure
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Biological Activity

T-1095 is a selective and orally active Na+-glucose cotransporter (SGLT) inhibitor with IC50s of 22.8 µM and 2.3 µM for human SGLT1 and SGLT2, respectively. T-1095 can be used for diabetes research.

Chemical Information
Molecular Weight 516.49
Formula C26H28O11
CAS Number 209746-59-8
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Akira Saito, et al. Nihon Rinsho. [SGLT inhibitor (T-1095)]

[2] Kumiko Nunoi, et al. Clin Exp Pharmacol Physiol. Beneficial effect of T-1095, a selective inhibitor of renal Na+-glucose cotransporters, on metabolic index and insulin secretion in spontaneously diabetic GK rats

[3] A Oku, et al. Biol Pharm Bull. Antihyperglycemic effect of T-1095 via inhibition of renal Na+-glucose cotransporters in streptozotocin-induced diabetic rats

[4] T Adachi, et al. Metabolism. T-1095, a renal Na+-glucose transporter inhibitor, improves hyperglycemia in streptozotocin-induced diabetic rats

[5] A Oku, et al. Diabetes. T-1095, an inhibitor of renal Na+-glucose cotransporters, may provide a novel approach to treating diabetes

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Keywords: T-1095  supplier, SGLT, inhibitors, activators

 
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