Free shipping on all orders over $ 500

Syzalterin

Cat. No. M14101
Syzalterin Structure
Size Price Availability
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Syzalterin is an inhibitor of NO production with an IC50 of 1.87 μg/mL.

Chemical Information
Molecular Weight 298.29
CAS Number 94451-48-6
Solubility (25°C)
Storage 2-8°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Zhi-Wen Duan, et al. [Non-alkaloid constituents of Hymenocallis littoralis]

[2] Susanna Alloisio, et al. Cannabis-like activity of Zornia latifolia Sm. detected in vitro on rat cortical neurons: major role of the flavone syzalterin

[3] Shi-wei Chai, et al. [Chemical constituents from whole plants of Valeriana hardwickii]

[4] Xin-Wei Lou, et al. Identification and characterization of three new flavonoids from Rhododendron dauricum

[5] So-Young Park, et al. C-methylflavonoids isolated from Callistemon lanceolatus protect PC12 cells against Abeta-induced toxicity

Related NOS Products
MAHMA NONOate

MAHMA NONOate is a NO donor. MAHMA NONOate effectively inhibits platelet aggregation induced by either collagen or ADP.

Inflexuside B

Inflexuside B, an abietane diterpenoid, can be isolated from the aerial parts of Isodon inflexus. Inflexuside B strongly inhibits lipopolysaccharide (LPS)-activated NO Synthase in RAW264.7 macrophages

Amcinonide

Amcinonide (Cyclocort, CL-34699) is an inhibitor of nitric oxide (NO) release from activated microglia with IC50 of 3.38 nM.

Bendazol

Bendazol (2-Benzylbenzimidazole, Dibazol, Dibazole, Bendazole, Tromasedan) is a hypotensive drug that enhances NO synthase activity in renal glomeruli and collecting tubules. Bendazol inhibits the progression of form-deprivation myopia (FDM) and suppresses the upregulation of HIF-1α.

L-NIO dihydrochloride

L-NIO dihydrochloride is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with Kis of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively.

  Catalog
Abmole Inhibitor Catalog




Keywords: Syzalterin supplier, NOS, inhibitors, activators

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.