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Synaptamide

Cat. No. M13918
Synaptamide Structure
Synonym:

Dehydroepiandrosteron(DHEA); Docosahexaenoyl ethanolamide

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Biological Activity

Synaptamide (Dehydroepiandrosteron; DHEA) is an endogenous metabolite and structural analogue of Anandamide. Synaptamide binds to both the cannabinoid-1 and 2 (CB1 and CB2) cannabinoid receptors and has anti-inflammatory properties. Synaptamide is the first small-molecule endogenous ligand of an adhesion G protein-coupled receptor (aGPCR) .

Chemical Information
Molecular Weight 371.56
CAS Number 162758-94-3
Solubility (25°C) Ethanol 25 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Anna Tyrtyshnaia, et al. Synaptamide Improves Cognitive Functions and Neuronal Plasticity in Neuropathic Pain

[2] Bill X Huang, et al. Synaptamide activates the adhesion GPCR GPR110 (ADGRF1) through GAIN domain binding

[3] Shilpa Sonti, et al. Metabolic studies of synaptamide in an immortalized dopaminergic cell line

[4] Taeyeop Park, et al. N-Docosahexaenoylethanolamine ameliorates LPS-induced neuroinflammation via cAMP/PKA-dependent signaling

[5] Hee-Yong Kim, et al. Synaptamide, endocannabinoid-like derivative of docosahexaenoic acid with cannabinoid-independent function

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Keywords: Synaptamide, Dehydroepiandrosteron(DHEA); Docosahexaenoyl ethanolamide supplier, Cannabinoid, inhibitors, activators


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