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Surfactin

Cat. No. M9921
Surfactin Structure
Size Price Availability Quantity
5mg USD 85  USD85 In stock
10mg USD 140  USD140 In stock
25mg USD 210  USD210 In stock
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Quality Control & Documentation
Biological Activity

Surfactin is a lipopeptide antibiotic that is composed of one β-hydroxy fatty acid, used as a surfactant to mediate flux of mono-and divalent cations, such as calcium, across lipid bilayer membranes, also used as adjuvant. It is a powerful biosurfactant that causes lysis of erythrocytes and bacteria. It is also a clotting inhibitor. Surfactin is thought to disrupt or disintegrate membranes via physicochemical interaction with the membranes.

Chemical Information
Molecular Weight 1036.34
Formula C53H93N7O13
CAS Number 24730-31-2
Solubility (25°C) Water 20 mg/mL
DMSO 30 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jiaxu Liu, et al. PLoS One. Sensitization of avian pathogenic Escherichia coli to amoxicillin in vitro and in vivo in the presence of surfactin

[2] Sun Young Park, et al. Toxicol Appl Pharmacol. Involvement of PKA and HO-1 signaling in anti-inflammatory effects of surfactin in BV-2 microglial cells

[3] Magali Deleu, et al. Biochim Biophys Acta. Effects of surfactin on membrane models displaying lipid phase separation

[4] Guillaume Henry, et al. Cell Microbiol. The bacterial lipopeptide surfactin targets the lipid fraction of the plant plasma membrane to trigger immune-related defence responses

[5] Liang-Ming Whang, et al. J Hazard Mater. Application of biosurfactants, rhamnolipid, and surfactin, for enhanced biodegradation of diesel-contaminated water and soil

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