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SU3327

Cat. No. M14161
SU3327 Structure
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Biological Activity

SU3327 is a potent, selective and substrate-competitive JNK inhibitor with an IC50 of 0.7 μM. SU3327 also inhibits protein-protein interactions between JNK and JNK Interacting Protein (JIP) with an IC50 of 239 nM. SU3327 shows less active against p38α and Akt kinase.

Chemical Information
Molecular Weight 261.3
CAS Number 40045-50-9
Solubility (25°C) DMSO 62.5 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yaru Xue, et al. Gigantol ameliorates CCl 4-induced liver injury via preventing activation of JNK/cPLA2/12-LOX inflammatory pathway

[2] Sehwan Jang, et al. Critical role of c-jun N-terminal protein kinase in promoting mitochondrial dysfunction and acute liver injury

[3] Sehwan Jang, et al. Inhibition of JNK aggravates the recovery of rat hearts after global ischemia: the role of mitochondrial JNK

[4] C Augustine, et al. Traumatic injury elicits JNK-mediated human astrocyte retraction in vitro

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Keywords: SU3327 supplier, JNK, inhibitors, activators

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