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Strictosidinic acid is an orally active glycoside indole monoterpene alkaloid, which inhibits precursor enzymes of 5-HT biosynthesis and reduces the 5-HT levels.
Strictosidinic acid (10 mg/kg; i.p.) causes a 63.4% reduction in 5-HT levels and a 67.4% reduction in DOPAC values in male Wistar rats, weighing 200-250 g. Strictosidinic acid has peripheral analgesic and antipyretic activities in mice.
| Molecular Weight | 516.54 |
| Formula | C26H32N2O9 |
| CAS Number | 150148-81-5 |
| Form | Solid |
| Solubility (25°C) | DMSO 100 mg/mL (ultrasonic) |
| Storage | 4°C, sealed |
[4] Rosane de P Castro, et al. Acta Crystallogr C. Absolute configuration of strictosidinic acid
| Related 5-HT Receptor Products |
|---|
| cis-Urocanic acid
cis-Urocanic acid is a 5-HT2A receptor agonist. cis-Urocanic acid binds to 5-HT receptor with relatively high affinity (Kd=4.6 nM). cis-Urocanic acid is also an immune modulator that induces immunosuppression. |
| 5-HT2B antagonist-1
5-HT2B antagonist-1 is an orally active 5-HT2B receptor antagonist with an IC50 value of 33.4 nM. |
| AS19
AS19 is a potent, selective 5-HT7 receptor agonist with an IC50 value of 0.83 nM and a Ki of 0.6 nM. |
| CP94253
CP94253 is a selective, orally active agonist for serotonin receptor 1B (5-HT1B), through competitive binding with iodocyanopindolol (ICP) to the 5-HT1 receptor. |
| RS 39604
RS 39604 is a potent, selective, and orally active 5-HT4 receptor antagonist with a pKi of 9.1 in guinea pig striatal membranes. |
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